Though this is not a trick but only a shortcut delete temporary files. Normally what most of us do to delete temporary files “Goes through the C:\Documents and Settings\Default User\Local Settings\Temp and delete whatever files are their. But this way they miss if their are multiple user profiles.
Now to get through the temp file location the best way to go through just press Windows key + R (Run menu) and in text box type %temp% this will show the temporary files location for that current user profile. There you can delete all the files from the folder.
But before deletion make sure you have saved all your work and none of any application running, unless it may cause to loose your work…